Though pine back can be extremely valuable, as with anything, its important to be aware of all of the possible side effects. This causes them to be ionic (charged) molecules. Pine Bark Extract is thought to be most safe when it is taken daily, by mouth in doses of 50 to 450 mg and when applied to your skin as a cream for up to seven days, in some cases, pine back extract is known to cause gut problems, mouth ulcers and headaches. Antioxidants are able to neutralize the ionic charge of the radical oxygen molecules and thereby reducing the side effects of oxidant-based cellular damage. 3-Bleeding. Looking for a supplement of pine bark extract for skin, blood, and heart health? You can think of it kind of like the drains and piping in your house — when gunk builds up over time causing blockages. As suggested by the Cancer Supportive Survivorship Care website, the same protective effects that antioxidants have against damaging reactive oxygen species in normal tissue also can often inhibit the toxic effects of chemotherapy drugs. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. ), allergies, pre-existing diseases, and current health conditions (e.g. What pine bark extract appears to do is reduce the oxidative stress that leads to the formation of circulatory and blood disorders in the first place. The best pine bark extract OPC, made and certified in France, costs up to $3000 a kilogram, while a pine bark extract or a grape seed extract from China costs only $70-$100 [...] a kilogram. As they they travel through the human body, they are searching for other molecules to bump into and remove electrons from. No ill side effects have been observed or reported with doses ranging between 75 and 475 milligrams per day. Although scientific research, to a limited extent, supports many of these claims, few of the studies have utilized clinical trials, and fewer have focused on potential safety issues of this compound. According to a 1999 article in "Free Radical Biology and Medicine," pine bark extract inhibits the activity of angiotensin-converting enzyme, or ACE, an essential enzyme in the regulation of hypertension. Pine bark extract has poorly understood effects on the immune system, however, several reports have indicated possible immunosuppressant properties of this compound. medium-sized pines growing up to 30 m tall with bright red-brown Acne 2. This benefit was seen after 2 months of use and the untreated control group didn’t experience the same improvement. Buy Pine Bark Extract. In rare cases of over-supplementation, pine bark extract has been known to cause mild stomach upset, dizziness, headaches and/or temporary mouth ulcerations. Advocates of pine bark extract suggest that this compound and similar related compounds have protective effects against many disorders, including arthritis, diabetes, cancer and heart disease. Side Effects. Pycnogenol® (pronounced pic-NOJ-en-all) is the trade name for an extract of French Maritime Pine Bark (Pinus pinaster). He has published several scientific abstracts for the American Association for Cancer Research and has also published articles in the "International Journal of Oncology." Currently, there’s little evidence to suggest that pine bark has any significant downsides or side effects in the general population (2, 8, 81). Also, many people use pycnogenol for erectile dysfunction, which suggests that there is a correlation. It is also possible that you could have an allergic reaction to pine bark extract, which could range from mild to potentially life-threatening complications. Other Side Effects and Warnings. Pycnogenol contains concentrated levels of unique flavonoid compounds. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Pine Bark Extract. Scientific evidence supporting … For example, in a 2003 article in "Phytotherapy Research," researchers report the finding that in rats, pine bark extract can inhibit histamine release, an important regulator of the allergic response. Hangovers 4. 2008, Kim SH, Lee IC, Lim JH, Moon C, Bae CS, Kim SH, Shin DH, Park SC, Kim HC, Kim JC. Then it is necessary to dissolve these blockages with a drain rooter or dissolving agent. Your email address will not be published. Pine bark extract may not be safe for people with a weakened immune system. Pine pollen is used to promote healing and protect against a wide range of issues, including: 1. Free radicals (oxidants) are unstable molecules because they have electrons that are unpaired. Before using Pine Bark Extract, inform your doctor about your current list of medications, over the counter products (e.g. Pycnogenol side effects There is currently not enough research to determine whether or not taking pine bark extract is safe for women who are pregnant or breastfeeding. However, it is recommended to start with the lowest possible dose until you know how your body will react. Similar reported side effects are commonly associated with many dietary supplements. Save my name, email, and website in this browser for the next time I comment. Adverse Effects of Pine Bark Extract Common Transient Side Effects. Pine bark extract may also increase the risk of bleeding, which could worsen effects of blood thinners such as ibuprofen or warfarin. Consult your doctor or health care professional … Epub 2018 Dec 12. Further, humans actually synthesize free radical substances via various endogenous (inner) metabolic activities. The legality and side effects of Pine Bark Extract. Pcynogenol Reviews - health benefits and side effects Pycnogenol is an extract from the bark of French Maritime Pine trees that grow in the Landes Forest of southwestern France. Side effects Interactions. Some people report feeling dizzy after the initial doses of French Maritime Pine Bark Extract. A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. 2014, Anti-oxidant, anti-inflammatory & neuroprotective. Behav Pharmacol. J Cancer Prev. Pine Extract Has an Antioxidant Effect. You might use pine bark extract or pycnogenol to help treat a variety of medical conditions, including chronic venous insufficiency, retinopathy or erectile dysfunction. Pycnogenol can boost your immune system. To this point, there have been no conclusive determinations made from leading healthcare authorities concerning its effectiveness to prevent or cure any disease. A Web Experience brought to you by LEAFtv, Cancer Supportive Survivorship Care: Complementary Medications and Chemotherapy, Wiley Online Library: Pycnogenol® Inhibits the Release of Histamine from Mast Cells. 2009, Yang IH, Shin JA, Cho SD. It is sometimes used as an alternative treatment for several conditions including hypertension, erectile dysfunction and ADHD. Those with any autoimmune condition including, but not limited to lupus, MS (multiple sclerosis) and (RA) rheumatoid arthritis; Anyone with a condition that affects bleeding/clotting capacities; Anyone scheduled for any surgical procedure within the next 2 weeks. Protective effects of pine bark extract on developmental toxicity of cyclophosphamide in rats. So if you’re on medication for auto-immune diseases like multiple sclerosis (MS), lupus, rheumatoid arthritis and others. He holds a Ph.D. in pharmacology and toxicology from Washington State University. Jpn J Infect Dis. In powder form, usage for six straight weeks presented no side effects. The extract from the bark of the French maritime pine, Pycnoge … Pleiotropic Effects of French Maritime Pine Bark Extract to Promote Healthy Aging Rejuvenation Res. opc-1-2-3.com. Eczema 3. Risks . Jeffery Herman has been writing in science since 2003. It is a natural source of several antioxidants including proanthocyanidins, which are also found in wine, grapes, apples, cocoa, tea, nuts, and some berries. OPCs in pine bark extract are some of the most powerful known antioxidants. They are chaotic and move randomly. For the 20 patients using the pine bark and bilberry extract, their intraocular pressure decreased from 25.2 to 22.2 mmHg. Phytother Res. Side Effects of Pine Bark Extract. What’s more, pine pollen is sometimes marketed as an adaptogen—a natural substance used to increase your body’s resistance to the negative effects of stress. High doses may also cause a drop in blood sugar levels in diabetics and interfere with liver function in people with hepatitis. Side Effects & Safety When taken by mouth: Willow bark is POSSIBLY SAFE for most adults when taken for up to 12 weeks. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Pine bark extract may result in some side effects such as headaches, dizziness, gastrointestinal problems, and ulcers in the mouth. Pycnogenol is similar to Grape Seed Extract and Cocoa Polyphenols as those are the three most common sources of Procyanidins. Pycnogenol supplementation is usually well tolerated in all volunteers and is possibly safe at recommended doses up to 6 weeks. No major side-effects have been reported in previous trials, although minor side-effects include stomach upsets and headaches. Long term usage of up to one year seems to have no increase of negative side effects. There are strong antioxidative constituents in pine bark called oligomeric proanthocyanidin compounds (OPCs). In general, pine bark extract is believed to be safe for human supplementation. Pycnogenol is a trademarked name for pine bark extract, and there is little to no difference between the two in terms of composition or effects. When used as a cream for the hands, ankles and feet, no side effects have been noted with daily use for seven days. In fact, it may inhibit histamine release and interfere with medication prescribed for immune function. It may cause headaches, stomach upset, and digestive system upset. This dietary supplement is officially called Pinus pinaster, and less commonly called Oligopin, Flavangenol and/or Pycnogenol. Pycnogenol Induces Nuclear Translocation of Apoptosis-inducing Factor and Caspase-independent Apoptosis in MC-3 Human Mucoepidermoid Carcinoma Cell Line. However, since the safety of pine bark extract is not fully investigated in humans, any adverse reaction, mild or otherwise, could potentially be a sign of bigger underlying issues and should not be ignored. Common side effect are usually mild such as vertigo, headache, gastrointestinal problems and nausea [9]. Required fields are marked *. Possible pine bark extract side effects include dizziness, intestinal upset, headaches and/or mouth ulcerations, but these effects are rare. The pine bark extract originates from the French and Maritime Provinces of Canada. Your email address will not be published. vitamins, herbal supplements, etc. Commonly sold under the trade-name Pycnogenol®, pine bark extract is an herbal antioxidant supplement derived from the French maritime pine tree (Pinus maritima). 2019 Jun;22(3):210-217. doi: 10.1089/rej.2018.2095. Pine bark extract may decrease blood sugar levels and should be used cautiously in patients suffering from hypoglycemia or diabetes, according to Medline Plus. They lodge wherever they can and initiate cellular reactions that result in significant damage. Side effects for Pine Bark Extract and Pycnogenol are rare when taken in doses from 50 – 450 mg daily. For this reason, according to the MedlinePlus website, pine bark extract can potentially interact with blood pressure-lowering medications, particularly with ACE-inhibitors such as enalapril and captopril. It may also have memory enhancing effects. Heart disease 5. Antioxidants like pine bark extract pills have the ability to stop the actions of free radicals. Discovered in 1535, eastern white pine bark has been used extensively for a variety of medicinal purposes by the Native people of Canada. His scientific research focuses on alternative dietary therapies for cancer treatment. Pycnogenol, which is extracted from the bark of the French maritime pine tree, may have anti-inflammatory, antioxidant and immune-stimulating effects 4 5. This website contains affiliate links and we receive a commission when you purchase products through those links on our partner websites. In addition, oxidant levels are shown to elevate with chronic illnesses, sedentary lifestyles and ineffective or nonexistent stress coping capacities. Side effects of Pine Bark Extract 1-Nausea. pregnancy, upcoming surgery, etc. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. In order to inhibit the destructive effects of oxidant actions in the body, we require the assistance of antioxidants. Other beneficial phytonutrients in Pinus pinaster are known to induce vasorelaxing effects, which in turn bring about various cardiovascular benefits. Clinical research is continuously underway from private, public, university and governmental institutions addressing its capacities to affect human health on numerous levels. Immune System Side Effects. Pycnogenol may also cause some mild headache episodes that pass soon after the first weeks. The best choice for those considering the benefits of Pinus pinaster extract supplementation is to ask their doctors about it first. You should speak to your doctor before using this supplement to determine whether it is safe for you based on your individual medical history and any other drugs you are using. In this video you'll discover the nootropic benefits of Pine Bark Extract. Pine bark extract may also interfere with medication used to boost immune function. Oxidative damage is widely believed to cause the onset of numerous side effects, diseases and conditions that are preventable in many cases. ).Some health conditions may make you more susceptible to the side-effects of the drug Consistently nutritious dietary intake plans that omit fried, deep-fried, bleached, sugar-laden, high-fat, processed, prepared, packaged and otherwise unhealthy food sources; Daily physical activity to the point of perspiration for at least thirty minutes; Minimization of free radical synthesis and exposure; Consistently efficient stress management techniques; Other healthy lifestyle modification choices as necessary. Efficacy As mentioned above, there are pycnogenol side effects, which include and enhanced mood, but obviously this is more of a benefit than a true “side effect”. Possible pine bark extract side effects include dizziness, intestinal upset, headaches and/or mouth ulcerations, but these effects are rare. As reported by the American Cancer Society, most reported pine bark extract side effects are mild and transient. 2012, Belcaro G, Dugall M, Luzzi R, Hosoi M, Corsi M. Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. This is a primary motivator for continuing clinical research on Pinus pinaster. In most supplementation cases, pine bark extract generates no adverse effects at all. You should always consider the risks of a nootropic before you use it. All current clinical proof shows strong promise for uncovering more human health benefits of supplementation. According to the Harvard School of Medicine, as much as 97% of all diseases are preventable – if certain conditions are met, including: Humans encounter free radicals in a variety of ways. It is a... 2-Migraines. Int J Angiol. The bark extract of pine trees in psoriasis is of high scientific interest, as more than 70 human studies have already investigated this mixture of active ingredients. These include nausea, headache and upset stomach. High cholesterol Pine pollen is also used to stimulate the immune system, boost brain health, support detox, promote weight loss, alleviate pain, and prevent some forms of cancer. While there is no direct evidence that pine bark extract will interact with cancer chemotherapeutic drugs, it is important to note that antioxidants are often contraindicated with such medicine. Food Chem Toxicol. TRU-PINE ® is made from eastern white pine bark. OPCs found in Pine Bark Extract capsules have been shown to be effective anti-oxidant agents. Although this supplement contains natural substances, some side effects have been reported, including – headaches, dizziness, nausea, and upset stomach. Very rarely will you experience dizziness, stomach problems, headache or mouth ulcers. 2014, Aoki H, Nagao J, Ueda T, Strong JM, Schonlau F, Yu-Jing S, Lu Y, Horie S. Clinical assessment of a supplement of Pycnogenol® and L-arginine in Japanese patients with mild to moderate erectile dysfunction. Environmental toxins are abundant in many forms: highway runoff, industrial pollutants, pesticides, herbicides and unhealthy mainstream food supply choices to name several. 2012, Ishrat T, Parveen K, Hoda MN, Khan MB, Yousuf S, Ansari MA, Saleem S, Islam F. Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. Pine bark extract supplementation has proven successful at reducing LDL cholesterol levels while raising HDL cholesterol levels at the same time. Groups that should not use Pinus pinaster without the explicit approval of their doctors include: Pinus pinaster from the southern regions of France is believed to have the highest concentrations of OPCs. In most supplementation cases, pine bark extract generates no adverse effects at all. Side Effects and Warnings. For this reason, pine bark extract may be contraindicated in people with a weakened immune system. Perimenopausal women who … It is used by doctors and laypeople of all developed countries to improve general states of health; and more specifically to treat a variety of health conditions and diseases, mainly those associated with circulatory insufficiencies. Consult your doctor. It is important to understand all the possibilities of condition or medication interactions in order to save yourself from any possible pine bark extract side effects. Pine bark extract may exacerbate the effects of immunosuppressant drugs, such as those prescribed for organ transplant recipients. Feng WY, Tanaka R, Inagaki Y, Saitoh Y, Chang MO, Amet T, Yamamoto N, Yamaoka S, Yoshinaka Y. Pycnogenol, a procyanidin-rich extract from French maritime pine, inhibits intracellular replication of HIV-1 as well as its binding to host cells. opc-1-2-3.com. Pine bark is considered safe for human use as there have been limited reports of side effects.
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